Retatrutide

Retatrutide is a triple hormone (GIP, GLP-1 and glucagon) receptor agonist in development for the treatment of obesity.

• Retatrutide works as a triple–hormone receptor agonist (GIP–GLP-1–GCG receptor agonists) by targeting three different hunger-regulating hormones:
  • GIP (gastric inhibitory peptide or glucose-dependent insulinotropic polypeptide) is an incretin hormone that is released from the gut after eating. It stimulates the beta-cells in the pancreas to secrete insulin.
  • GLP-1 (glucagon-like peptide-1) is also an incretin hormone that stimulates the beta-cells to secrete insulin.
  • GCG (glucagon) is a hormone secreted from the alpha-cells in the pancreas. It stimulates glucose production in the liver and helps maintain adequate plasma glucose concentrations.

FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION